If depressed, your chances of survival are best without pharma.
Of course, depression as such increases your chances of death but most commonly used drugs do too and none of them reduces the mortality rate.
Oswaldo P. Almeida et al. Depression, Antidepressant Use and Mortality in Later Life: The Health in Men Study. PLoS ONE 2010. Open access.
Of course, this says nothing about their effectivity in making you happy but the same can be said of heroine, right?
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